Serum biological markers including B-cells, immunoglobulins, and complement demonstrated statistically significant treatment effects consistent with expectations and previous blisibimod clinical studies in lupus and IgA nephropathy. Adverse events between the blisibimod and placebo treatment arms were well balanced and blisibimod was generally well tolerated.
"We are disappointed that the results did not demonstrate a meaningful improvement in patients' disease activity as assessed by SRI endpoints," said
The Company will continue to analyze the data in the coming weeks from the CHABLIS-SC1 trial in consultation with key lupus disease thought leaders to expeditiously determine the future of the blisibimod lupus program including the on-going CHABLIS 7.5 clinical study. As the pharmacological effects on immunological markers, such as B-cells and immunoglobulins, were as expected, the company is continuing the development of blisibimod for the treatment of IgA Nephropathy (IgAN) pending 48 week results from the ongoing phase 2 BRIGHT study. IgAN has a very different pathogenesis than systemic lupus, and the pharmacological activity of blisibimod might prove effective in its treatment. The Company expects to report 48-week data from the BRIGHT-SC IgAN study and topline data from the Sollpura™ SOLUTION phase 3 study later this year.
Anthera will host a conference call to further discuss the data from the CHABLIS-SC1 clinical study.
Conference Call Access:
Conference ID: 18122260
Toll-Free Dial-In Number: (855) 226-3021
International Dial-In Number: (315) 625-6892
Safe Harbor Statement
Any statements contained in this press release that refer to future events or other non-historical matters, including statements that are preceded by, followed by, or that include such words as "estimate," "intend," "anticipate," "believe," "plan," "goal," "expect," "project," or similar statements, are forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are based on Anthera's expectations as of the date of this press release and
are subject to certain risks and uncertainties that could cause actual results to differ materially as set forth in Anthera's public filings with the
Nikhil Agarwalof Anthera Pharmaceuticals, Inc., email@example.com or 510.856.5600 x5621
News Provided by Acquire Media